San Francisco @ Arizona
Team Totals: 49ers 25.5, Cardinals 22.5
Finally back from a painful turf toe condition that cost him most of the last two months, Brock Purdy’s outlook is a mystery after he initially went down in Week 1, then aggravated the injury in Week 4. Purdy did bank respectable results of QB14 (Week 1) and QB13 (Week 4) in his early-season appearances, but Arizona is a formidable foe, yielding the NFL’s eighth-fewest yards per pass attempt (6.8) and seventh-lowest passer rating (86.4). The Cardinals have allowed the league’s seventh-fewest fantasy QB points. … To compensate for a potentially injury-hindered quarterback and a certainly decimated defense, Kyle Shanahan’s offense should continue to revolve around Christian McCaffrey, who already leads the NFL in touches (249) and has 69 catches, 20 more than any other back. Arizona has posed a middling matchup for running backs this year. CMC’s draw is improved by the absence of Cardinals MLB Mack Wilson (ribs) and OLB Baron Browning (concussion).
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