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Denver @ San Francisco

Team Totals: 49ers 25.5, Broncos 22.5

This is a plus spot for Bo Nix facing a severely depleted, Nick Bosa-less 49ers defensive front that hit Jacoby Brissett on only five of 54 dropbacks in Week 3 and gave up fantasy’s QB5 finish. Behind Brandon Thorn’s No. 1-rated offensive line, Nix should be able to stand and comfortably deliver from a squeaky-clean pocket. I’m on the over on this game’s 47.5-point total and am buying Nix as a breakout-week QB1. … J.K. Dobbins’ Weeks 1-3 touch counts were 8, 10, and 18, although Dobbins is scoreless with one catch on the year. RJ Harvey is Denver’s go-to back in receiving situations. Despite their defensive personnel losses, the 49ers have held enemy backs to a 74/295/1 (3.99 YPC) rushing line. Dobbins is a touchdown-dependent flex option at San Francisco. Harvey is unplayable in all leagues.

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