San Francisco @ Arizona
Team Totals: Cardinals 27.5, 49ers 22
Expected to start in place of Jimmy Garoppolo (calf) with a realistic chance to run away with the 49ers’ starting QB job based on performance, Trey Lance’s fantasy upside is through the roof after he scored 20.4 points in two quarters off the bench in Week 4. The Cardinals have allowed the league’s seventh-most QB rushing yards (100), noteworthy since Lance scored 18 rushing TDs and averaged 69.7 rushing yards in 19 college games. If Lance does get the first-team nod, I’m starting him confidently here. … Trey Sermon was far more decisive on his Week 4 runs but drew zero passing-game targets and risks losing Week 5 work to Elijah Mitchell should Mitchell return from his two-week shoulder injury.
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