San Francisco @ L.A. Rams
Team Totals: Rams 25.5, 49ers 19
With few exceptions, the 49ers’ offense is among Week 12’s most difficult to handicap with Brandon Aiyuk and LT Trent Williams on the Covid list, Jordan Reed (illness) listed as questionable, RB Tevin Coleman (knee) ruled out, and RBs Raheem Mostert (ankle) and Jeffrey Wilson (ankle) eligible to come off I.R. but facing role uncertainty. As just 2-of-10 quarterbacks to face the Rams have banked fantasy finishes higher than QB17, Nick Mullens is only two-QB-league viable here. … Although San Francisco’s running-game matchup improved when the Rams lost leading tackler ILB Micah Kiser (knee) to I.R., the 49ers backfield’s lack of workload definition makes it a fantasy situation to avoid barring early-Sunday reports that provide some semblance of clarity. Mostert, Wilson, Jerick McKinnon, and Austin Walter are all technically eligible, yet Kyle Shanahan was noncommittal Friday on their usage distribution.
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