Kansas City @ Buffalo
Team Totals: Chiefs 31, Bills 26.5
Patrick Mahomes visits Buffalo for an unexpected smash spot with Sean McDermott’s underachieving defense having conceded top-14 QB fantasy finishes in four straight games. All told, quarterbacks in Weeks 2-5 went 107-of-151 (71%) passing for 1,155 yards with a 9:1 TD-to-INT ratio and two additional rushing scores against the Bills. In the same timeframe, McDermott’s team coughed up 31.3 points per game. Especially as Buffalo’s offense has played at its peak – enhancing this game’s shootout potential – Mahomes’ ceiling is as lofty as ever here. … Averaging 18.3 touches and 6.3 targets over the last month, Clyde Edwards-Helaire draws potentially his last opportunity for a true eruption game following Kansas City’s signing of Le’Veon Bell. No Week 6 contest is totaled higher than Chiefs-Bills (57.5), while running backs facing Buffalo have averaged a rushing touchdown per game.