Last updated: December 28th at 10:30pm ET



Team Totals: 49ers 25, Seahawks 22

Both Sunday Night Football teams have lots on the line, which is precisely why this game was flexed into primetime. The Niners can clinch the NFC’s No. 1 playoff seed and homefield advantage throughout the postseason with a victory at CenturyLink Field, while the Seahawks can overtake San Francisco for that distinction with a Sunday night win and Packers loss at Detroit earlier in the day. Even if Green Bay wins as expected, Seattle can clinch the NFC West, earn a first-round bye, and force San Francisco to play in the Wild Card Round by defeating its division rival here.

Thus, everyone is going all out. Jimmy Garoppolo, Raheem Mostert, George Kittle, Emmanuel Sanders, and Deebo Samuel are the 49ers’ obvious plays on one-game DFS slates. No. 3 WR Kendrick Bourne has made just enough scoring-position noise for punt-play discussion.

Exacerbated by LT Duane Brown’s (knee scope) absence, Seattle’s passing game lost its trustworthiness during a second-half rut. But San Francisco’s defense isn’t as fearsome as it was early in the season, having yielded 26.5 points per game over its last eight. Russell Wilson, Tyler Lockett, and D.K. Metcalf are locked into major roles in an overrated matchup. Seahawks Week 16 receiving leader Jacob Hollister remains very playable, especially since his draw was improved when the 49ers listed tight end stopper Jaquiski Tartt (ribs) as doubtful on Friday. And No. 2 TE Luke Willson (hip, hamstring) was a late addition to Seattle’s injury report, enhancing Hollister’s opportunity.

The Seahawks will likely lean on a three-man RBBC involving newly signed Marshawn Lynch and Robert Turbin plus rookie Travis Homer, who drew eight Week 16 targets and figures to operate on passing downs. Homer is a PPR-oriented sleeper on one-game DFS slates. I’m expecting Lynch to lead Seattle in carries but not to dominate the backfield in his first NFL appearance since October 14, 2018.

But the top one-game DFS sleeper on either side is arguably David Moore, who was elevated up the depth chart over the past two weeks by Josh Gordon’s suspension and Malik Turner’s concussion. Moore has flashed big-time playmaking ability in the past, and he now projects as Seattle’s No. 3 wide receiver behind Lockett and Metcalf against San Francisco.

Score Prediction: Seahawks 24, 49ers 23