Arizona @ Buffalo
Team Totals: Bills 27.5, Cardinals 20.5
On top of being further removed from 2022’s ACL/meniscus tear, Kyler Murray’s box-score appeal is rooted in Arizona’s weekly team-shootout potential with explosive weapons on an offense that must compensate for the NFL’s least-talented defense. (I really like the over on this game’s 48-point total.) Murray’s Week 1 matchup improved when the Bills lost ILB Matt Milano (torn bicep) in camp; rangy Milano may have been used as a “spy” to chase Kyler on scrambles. … I faded James Conner in redraft leagues because he’s 29 with nearly 1,400 touches on his tires, a lengthy injury history, and added competition after the Cards drafted big-play runner Trey Benson with April’s 66th overall pick. But there is no question about his 2023 performance; Conner was a top-15 back or better in yards per carry and yards created amid bottom-barrel run blocking. Milano’s absence is also certain to be felt by Buffalo’s run defense. I like Conner’s chances of hovering in the 16-20 touches range in Arizona’s opener.
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