Arizona @ Indianapolis
Team Totals: Colts 27, Cardinals 20.5
Assuming Kyler Murray (foot) misses Week 6, the Cardinals will turn to nearly 33-year-old journeyman Jacoby Brissett, who’s on his seventh NFL team in 10 seasons. Immobile, inaccurate, and a sack waiting to happen, Brissett is an attack target for Indy’s D/ST. Under first-year DC Lou Anarumo, 2025’s Colts rank top five in sacks (14) and have allowed the league’s third-fewest points. … Michael Carter stepped in as Arizona’s Week 5 lead back against the Titans but had a long run of seven yards on 18 carries and managed 22 yards on five targets. Carter was inefficient, yet Emari Demercado’s play was even more egregious, dropping the ball while crossing the goal line to negate an early fourth-quarter 72-yard touchdown that would’ve put the Cards up 28-6. The Colts have allowed the NFL’s seventh-fewest fantasy RB points. I’m treating Carter as a low-floor, TD-dependent flex option.
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