San Francisco @ Carolina
Team Totals: 49ers 22.5, Panthers 16
Missing All-Pro LT Trent Williams (high ankle sprain) and fill-in Colton McKivitz (MCL) on a short-week road trip against dangerous Panthers EDGE rushers Brian Burns and Yetur Gross-Matos, Kyle Shanahan seems certain to devise a run-heavy and/or quick-pass offense that encourages Jimmy Garoppolo to get the ball out as fast as possible while continuing to lean on Jeff Wilson. Wilson enters Week 5 with touch counts of 20, 15, and 18 in Weeks 2-4, while enemy backs have carved Carolina for a combined to-date rushing line of 100/458/2 (4.6 YPC). I like Jimmy G as a mid-range QB2 option and Wilson as a volume-secure RB2. … Deebo Samuel leads San Francisco in targets (20), catches (16), yards (232), TDs (1), and first-down conversions (8) on Garoppolo’s 2022 throws and is always a threat to bust a long run.
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