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San Francisco @ Tampa Bay

Team Totals: 49ers 28.5, Bucs 22

This is an eruption spot for Brock Purdy with his supporting cast at near-full strength facing a Bucs defense that let up fantasy results of QB5 (Patrick Mahomes), QB3 (Kirk Cousins), and QB1 (Lamar Jackson) in its last three games. On the year, Tampa has yielded the NFL’s sixth-highest passer rating (101.1). The Bucs will be without top CB Jamel Dean (hamstring, I.R.) and first-team SS Jordan Whitehead (quad). … All signs point to Christian McCaffrey (Achilles) making his 2024 debut at Tampa. 49ers No. 2 RB Jordan Mason is still battling a recurring AC joint shoulder sprain. I’m not forecasting a full workload for CMC here — Isaac Guerendo has made a substantive case for change-of-pace, between-the-tackles carries — but McCaffrey is always an elite RB1 option when active. The Bucs have coughed up the NFL’s third-most catches (54) and third-most receiving yards (439) to enemy running backs.

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