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San Francisco @ NY Giants
Team Totals: 49ers 23, Giants 19

In what they hope will be a short-term absence for Jimmy Garoppolo (high ankle sprain), the 49ers are turning to 2018 eight-game starter Nick Mullens against the G-Men. Although Mullens acquitted himself well two seasons ago – 8.3 YPA, 4.7% TD Rate – he will play Sunday’s game at a major disadvantage missing Raheem Mostert (knee), Tevin Coleman (knee), Deebo Samuel (foot), C Weston Richburg, and (probably) George Kittle (knee). Even in a plus draw, San Francisco’s shorthanded supporting cast renders Mullens a low-end two-QB-league option. … Due to wideout and tight end shortages, the 49ers enter Week 3 having thrown a league-high 37% of their passes to running backs, while Bears RBs caught a perfect 7-of-7 targets for 70 yards and a touchdown against the Giants last week. This bodes well for early-season sparkplug Jerick McKinnon, who is unlikely to inherit post-Mostert and Coleman workhorse duties but has a realistic chance to operate as the focal point of San Francisco’s Week 3 passing game. … 49ers beat writers expect Jeffrey Wilson to lead the team in Week 3 carries, giving Wilson flex-play life in a plum spot. Giants DC Patrick Graham’s unit served up 130-plus rushing yards in each of its first two games. … With Mostert’s timeline uncertain and Coleman out for at least a month, deep leaguers need to get familiar with UDFA rookie JaMycal Hasty, who is likely to factor into the Niners’ backfield mix.

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