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Arizona @ San Francisco
Team Totals: 49ers 27.25, Cardinals 20.25

The Cardinals kick off the season facing a 49ers defense at risk of taking a significant step back. DEs Nick Bosa (leg) and Dee Ford (calf) missed most of camp, DT DeForest Buckner was dealt to Indy, DBs coach Joe Woods took Cleveland’s defensive coordinator job, star ILB Fred Warner was placed on the Covid list on August 31, No. 2 cornerback remains unresolved, and Richard Sherman is a year older. All of this bodes well for Kyler Murray, who banked overall QB8 (last Week 9) and QB6 (Week 11) finishes against 49ers DC Robert Saleh’s unit, which yielded the NFL’s third-most QB rushing yards per game (23.8) and looks shorthanded entering this year.

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