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San Francisco @ Pittsburgh

Team Totals: 49ers 22, Steelers 20

Likely to continue to be deployed as a game manager quarterbacking a balanced-to-run-first team, Brock Purdy averaged just 26.1 pass attempts during his seven wire-to-wire 2022 starts (including playoffs) and has never offered much as a rusher. Purdy is a low-end QB2 bet against Pittsburgh’s talent-rich defensive front featuring T.J. Watt, Alex Highsmith, Cameron Heyward, and Larry Ogunjobi. … Christian McCaffrey averaged 111.3 all-purpose yards and 1.1 TDs over his final 13 games for last year’s 49ers while earning a lofty 20.5% target share on throws from Purdy. Mismatches favoring Pittsburgh’s defense in the trenches suggest McCaffrey will play a major receiving role on quick hitters designed to get the ball out of Purdy’s hands fast. … Elijah Mitchell earned 10.5 touches per regular-season game after McCaffrey’s acquisition from Carolina and banked touch totals of 11 and 14 in two playoff appearances. He’s an elite handcuff.

Predicting the weekly production of George Kittle, Deebo Samuel, and Brandon Aiyuk will be a season-long adventure, although point guard-style distributor Purdy is the right man for the job. Kittle scored seven touchdowns on only 34 targets from Purdy in 2022 and over the course of last season ranked No. 2 among NFL tight ends in snap rate (91%), No. 5 in receiving yards (765), and No. 2 in TDs (11). Aiyuk led the 49ers in targets (39), catches (27), yards (349), and first-down conversions (17) on Purdy’s throws.

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